Just some of the recent publications of our students:

Heifets BD, Chevaleyre V, Castillo PE.Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin. Proc Natl Acad Sci U S A. 2008 Jul 22. 105(29):10250-10255.

Ross R, Wang PY, Chari M, Lam CK, Caspi L, Ono H, Muse ED, Li X, Gutierrez-Juarez R, Light PE, Schwartz GJ, Rossetti L, Lam TK. Hypothalamic PKC regulates glucose production. Diabetes. 2008 May 28. [Epub ahead of print]

Alvarez M, Saylor C, Casadevall A. Antibody action after phagocytosis promotes Cryptococcus neoformans and Cryptococcus gattii macrophage exocytosis with biofilm-like microcolony formation. Cell Microbiol. 2008 May 16. [Epub ahead of print]

Einstein FH, Fishman S, Bauman J, Thompson RF, Huffman DM, Atzmon G, Barzilai N, Muzumdar RH. Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance. FASEB J. 2008 Jun 19. [Epub ahead of print].

Friedman AJ, Han G, Navati MH, Chacko M, Gunther L, Alfieri A, Friedman JM. Sustained release nitric oxide releasing nanoparticles: Characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites. Nitric Oxide. 2008 Aug; 19(1):12-20.

Pezo RC, Gandhi SJ, Shirley LA, Pestell RG, Augenlicht LH, Singer RH. Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors. Cancer Res. 2008 Jul 1; 68(13):4977-82.

Dictenberg JB, Swanger SA, Antar LN, Singer RH, Bassell GJ. A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome. Dev Cell. 2008 Jun; 14(6):926-39.

Stahl M, Uemura K, Ge C, Shi S, Tashima Y, Stanley P. Roles of Pofut1 and O-fucose in mammalian notch signaling. J Biol Chem. 2008 May 16; 283(20):13638-51.

Olabisi OA, Soto-Nieves N, Nieves E, Yang TT, Yang XY, Yu RY, Suk HY, Macian F, Chow CW. Regulation of transcription factor NFAT by ADP-Ribosylation. Mol Cell Biol. 2008 May; 28(9):2860-71.

Thompson RF, Reimers M, Khulan B, Gissot M, Richmond TA, Chen Q, Zheng X, Kim K, Greally JM. An analytical pipeline for genomic representations used for cytosine methylation studies. Bioinformatics. 2008 May 1; 24(9):1161-7.

Im JS, Kang TJ, Lee SB, Kim CH, Lee SH, Venkataswamy MM, Serfass ER, Chen B, Illarionov PA, Besra GS, Jacobs WR Jr, Chae GT, Porcelli SA. Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections. Clin Immunol. 2008 May; 127(2):214-24.

Peled JU, Kuang FL, Iglesias-Ussel MD, Roa S, Kalis SL, Goodman MF, Scharff MD. The Biochemistry of Somatic Hypermutation. Annu Rev Immunol. 2008 Apr; 26:481-511.

Mendez LM, Polo JM, Yu JJ, Krupski M, Ding BB, Melnick A, Ye BH. CtBP is an essential corepressor for BCL6 autoregulation. Mol Cell Biol. 2008 Apr; 28(7):2175-86.

Liao J, Aggarwal VS, Nowotschin S, Bondarev A, Lipner S, Morrow BE. Identification of downstream genetic pathways of Tbx1 in the second heart field. Dev Biol. 2008 Apr 15; 316(2):524-37.

Roday S, Sturm MB, Blakaj D, Schramm VL. Detection of an abasic site in RNA with stem-loop DNA beacons: Application to an activity assay for Ricin Toxin A-Chain. J Biochem Biophys Methods. 2008 Apr 24; 70(6):945-53.

Figueroa ME, Reimers M, Thompson RF, Ye K, Li Y, Selzer RR, Fridriksson J, Paietta E, Wiernik P, Green RD, Greally JM, Melnick A. An integrative genomic and epigenomic approach for the study of transcriptional regulation. PLoS One. 2008 Mar 26; 3(3):e1882.

Kiprilov EN, Awan A, Desprat R, Velho M, Clement CA, Byskov AG, Andersen CY, Satir P, Bouhassira EE, Christensen ST, Hirsch RE. Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery. J Cell Biol. 2008 Mar 10; 180(5):897-904.

Maglione PJ, Xu J, Casadevall A, Chan J. Fc{gamma} Receptors Regulate Immune Activation and Susceptibility during Mycobacterium tuberculosis Infection. J Immunol. 2008 Mar 1; 180(5):3329-38.

Chakravarty SD, Zhu G, Tsai MC, Mohan VP, Marina S, Kirschner DE, Huang L, Flynn J, Chan J. Tumor Necrosis Factor Blockade in Chronic Murine Tuberculosis Enhances Granulomatous Inflammation and Disorganizes Granulomas in the Lungs. Infect Immun. 2008 Mar; 76(3):916-26.

Gissot M, Choi SW, Thompson RF, Greally JM, Kim K. Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation. Eukaryot Cell. 2008 Mar; 7(3):537-40.

Roa S, Kuang FL, Scharff MD. Does antisense make sense of AID targeting? Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3661-2.

Braunstein EM, Crenshaw Iii EB, Morrow BE, Adams JC. Cooperative Function of Tbx1 and Brn4 in the Periotic Mesenchyme is Necessary for Cochlea Formation. J Assoc Res Otolaryngol. 2008 Mar; 9(1):33-43.

Harris AZ, Pettit DL. Recruiting Extrasynaptic NMDA Receptors Augments Synaptic Signaling. J Neurophysiol. 2008 Feb; 99(2):524-33.

Ding BB, Yu JJ, Yu RY, Mendez LM, Shaknovich R, Zhang Y, Cattoretti G, Ye BH. Constitutively activated STAT3 promotes cell proliferation and survival in the activated B cell subtype of diffuse large B-cell lymphomas. Blood. 2008 Feb 1; 111(3):1515-23.

Waller KL, McBride SM, Kim K, McDonald TV. Characterization of two putative potassium channels in Plasmodium falciparum. Malar J. 2008 Jan 24; 7:19.

Meyer-Bahlburg A, Andrews SF, Yu KO, Porcelli SA, Rawlings DJ. Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation. J Exp Med. 2008 Jan 21; 205(1):155-68.

Marsden KC, Beattie JB, Friedenthal J, Carroll RC. NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors. J Neurosci. 2007 Dec 26; 27(52):14326-37.

Stanton SE, Blanck JK, Locker J, Schreiber-Agus N. Rybp interacts with Hippi and enhances Hippi-mediated apoptosis. Apoptosis. 2007 Dec; 12(12):2197-206.

McReynolds LJ, Gupta S, Figueroa ME, Mullins MC, Evans T. Smad1 and Smad5 differentially regulate embryonic hematopoiesis. Blood. 2007 Dec 1; 110(12):3881-90.

Zhao Z, Burkly LC, Campbell S, Schwartz N, Molano A, Choudhury A, Eisenberg RA, Michaelson JS, Putterman C.TWEAK/Fn14 Interactions Are Instrumental in the Pathogenesis of Nephritis in the Chronic Graft-versus-Host Model of Systemic Lupus erythematosus. J Immunol. 2007 Dec 1; 179(11):7949-58.

Li Q, Ndonye RM, Illarionov PA, Yu KO, Jerud ES, Diaz K, Bricard G, Porcelli SA, Besra GS, Chang YT, Howell AR. Rapid identification of immunostimulatory alpha-galactosylceramides using synthetic combinatorial libraries. J Comb Chem. 2007 Nov-Dec; 9(6):1084-93.

Glass JL, Thompson RF, Khulan B, Figueroa ME, Olivier EN, Oakley EJ, Van Zant G, Bouhassira EE, Melnick A, Golden A, Fazzari MJ, Greally JM. CG dinucleotide clustering is a species-specific property of the genome. Nucleic Acids Res. 2007 Nov 1; 35(20):6798-6807.

Fernandes M, Gutin G, Alcorn H, McConnell SK, Hebert JM. Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly. Development. 2007 Nov; 134(21):3789-94.

Squires RC, Muehlbauer SM, Brojatsch J. Proteasomes control caspase-1 activation in anthrax lethal toxin-mediated cell killing. J Biol Chem. 2007 Nov 23; 282(47):34260-7.

Taylor EA, Rinaldo-Matthis A, Li L, Ghanem M, Hazleton KZ, Cassera MB, Almo SC, Schramm VL. Anopheles gambiae Purine Nucleoside Phosphorylase: Catalysis, Structure, and Inhibition. Biochemistry. 2007 Oct 30; 46(43):12405-15.

Harris AZ, Pettit DL. Extrasynaptic And Synaptic Nmdars Form Stable And Uniform Pools In Hippocampal Slices. J Physiol. 2007 Oct 15; 584(Pt 2):509-19.

Levsky JM, Shenoy SM, Chubb JR, Hall CB, Capodieci P, Singer RH. The spatial order of transcription in mammalian cells. J Cell Biochem. 2007 Oct 15; 102(3):609-17.

Mo Y, Quanquin NM, Vecino WH, Ranganathan UD, Tesfa L, Bourn W, Derbyshire KM, Letvin NL, Jacobs WR Jr, Fennelly GJ. Genetic Alteration of Mycobacterium smegmatis to Improve Mycobacterial Bactofection and DNA Immunization. Infect Immun. 2007 Oct;75(10):4804-16.

Kedrin D, van Rheenen J, Hernandez L, Condeelis J, Segall JE. Cell Motility and Cytoskeletal Regulation in Invasion and Metastasis. J Mammary Gland Biol Neoplasia. 2007 Sep;12(2-3):143-52.

Lapidus K, Wyckoff J, Mouneimne G, Lorenz M, Soon L, Condeelis JS, Singer RH. ZBP1 enhances cell polarity and reduces chemotaxis. J Cell Sci. 2007 Sep 15; 120(Pt 18):3173-8.

Morozov A, Lee SJ, Zhang ZK, Cimica V, Zagzag D, Kalpana GV. INI1 induces interferon signaling and spindle checkpoint in rhabdoid tumors. Clin Cancer Res. 2007 Aug 15; 13(16):4721-30.

Hinchey J, Lee S, Jeon BY, Basaraba RJ, Venkataswamy MM, Chen B, Chan J, Braunstein M, Orme IM, Derrick SC, Morris SL, Jacobs WR Jr, Porcelli SA. Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis. J Clin Invest. 2007 Aug; 117(8):2279-88.

Freundlich JS, Wang F, Tsai HC, Kuo M, Shieh HM, Anderson JW, Nkrumah LJ, Valderramos JC, Yu M, Kumar TR, Valderramos SG, Jacobs WR Jr, Schiehser GA, Jacobus DP, Fidock DA, Sacchettini JC. X-ray Structural Analysis of Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase as a Pathway toward the Optimization of Triclosan Antimalarial Efficacy. J Biol Chem. 2007 Aug 31; 282(35):25436-44.

Hunt P, Afonso A, Creasey A, Culleton R, Sidhu AB, Logan J, Valderramos SG, McNae I, Cheesman S, do Rosario V, Carter R, Fidock DA, Cravo P. Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites. Mol Microbiol. 2007 Jul; 65(1):27-40.

Kedrin D, Wyckoff J, Sahai E, Condeelis J, Segall JE. Imaging tumor cell movement in vivo. Curr Protoc Cell Biol. 2007 Jun; Chapter 19:Unit 19.7.

Chevaleyre V*, Heifets BD*, Kaeser PS, Sudhof TC, Castillo PE. Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1alpha. Neuron. 2007 Jun 7; 54(5):801-12. *Contributed equally.

Maglione PJ, Xu J, Chan J. B cells moderate inflammatory progression and enhance bacterial containment upon pulmonary challenge with Mycobacterium tuberculosis. J Immunol. 2007 Jun 1; 178(11):7222-34.

Muse ED, Lam TK, Scherer PE, Rossetti L. Hypothalamic resistin induces hepatic insulin resistance. J Clin Invest. 2007 June 1; 117(6):1670–1678.

Hegde SS, Chandler J, Vetting MW, Yu M, Blanchard JS. Mechanistic and Structural Analysis of Human Spermidine/Spermine N(1)-Acetyltransferase(,). Biochemistry. 2007 Jun 19;46(24):7187-95.

Pezo RC, Singer RH. Nuclear microenvironment in cancer diagnosis and treatment. J Cell Biochem. 2007 May 3; [Epub ahead of print]

Yu KO, Im JS, Illarianov PA, Ndonye RM, Howell AR, Besra GS, Porcelli SA. Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d. J Immunol Methods. 2007 May 31;323(1):11-23.

Li D, Kabir M, Stuehr DJ, Rousseau DL, Yeh SR. Substrate- and Isoform-Specific Dioxygen Complexes of Nitric Oxide Synthase. J Am Chem Soc. 2007 May 30;129(21):6943-51.

Pineda JR, Callender R, Schwartz SD. Ligand Binding and Protein Dynamics in Lactate Dehydrogenase. Biophys J. 2007 May 4; 93:1474-1483

Mikkelsen TS, Wakefield MJ, Aken B, Amemiya CT, Chang JL, Duke S, Garber M, Gentles AJ, Goodstadt L, Heger A, Jurka J, Kamal M, Mauceli E, Searle SM, Sharpe T, Baker ML, Batzer MA, Benos PV, Belov K, Clamp M, Cook A, Cuff J, Das R, Davidow L, Deakin JE, Fazzari MJ, Glass JL, Grabherr M, Greally JM, Gu W, ...et al... Broad Institute Whole Genome Assembly Team ... et al. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature. 2007 May 10;447(7141):167-77.

Sturm MB, Roday S, Schramm VL. Circular DNA and DNA/RNA Hybrid Molecules as Scaffolds for Ricin Inhibitor Design. J Am Chem Soc. 2007 May 2;129(17):5544-50.

Mukherjee S, Chiu R, Leung SM, Shields D. Fragmentation of the Golgi apparatus: an early apoptotic event independent of the cytoskeleton. Traffic. 2007 Apr;8(4):369-78.

Vetting MW, Hegde SS, Hazleton KZ, Blanchard JS. Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein. Protein Sci. 2007 Apr;16(4):755-60.

Hulit J, Suyama K, Chung S, Keren R, Agiostratidou G, Shan W, Dong X, Williams TM, Lisanti MP, Knudsen K, Hazan RB. N-Cadherin Signaling Potentiates Mammary Tumor Metastasis via Enhanced Extracellular Signal-Regulated Kinase Activation. Cancer Res. 2007 Apr 1;67(7):3106-16.

Muehlbauer SM, Evering TH, Bonuccelli G, Squires RC, Ashton AW, Porcelli SA, Lisanti MP, Brojatsch J. Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis. Cell Cycle. 2007 Mar 7; 6(6):758-66.

Medina FA, Cohen AW, de Almeida CJ, Nagajyothi F, Braunstein VL, Teixeira MM, Tanowitz HB, Lisanti MP. Immune dysfunction in caveolin-1 null mice following infection with Trypanosoma cruzi (Tulahuen strain). Microbes Infect. 2007 Mar; 9(3):325-33.

Eugenin EA, King JE, Nath A, Calderon TM, Zukin RS, Bennett MV, Berman JW. HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3438-43.

Li Z, Luo Z , Ronai D, Kuang FL, Peled JU, Iglesias-Ussel MD, Scharff MD. Targeting AID to the Ig genes. Adv Exp Med Biol. 2007 596:93-109.

Chakravarty SD, Xu J, Lu B, Gerard C, Flynn J, Chan J. The Chemokine Receptor CXCR3 Attenuates the Control of Chronic Mycobacterium tuberculosis Infection in BALB/c Mice. J Immunol. 2007 Feb 1; 178(3):1723-35.

Forestier C, Takaki T, Molano A, Im JS, Baine I, Jerud ES, Illarionov P, Ndonye R, Howell AR, Santamaria P, Besra GS, Dilorenzo TP, Porcelli SA. Improved Outcomes in NOD Mice Treated with a Novel Th2 Cytokine-Biasing NKT Cell Activator. J Immunol. 2007 Feb 1; 178(3):1415-25.

Sidhu AB, Sun Q, Nkrumah LJ , Dunne MW, Sacchettini JC, Fidock DA. In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin. J Biol Chem. 2007 Jan 26; 282(4):2494-504.

Zafonte BT, Liu S, Lynch-Kattman M, Torregroza I, Benvenuto L, Kennedy M, Keller G, Evans T. Smad1 expands the hemangioblast population within a limited developmental window. Blood. 2007 Jan 15; 109(2):516-23.

Knuth ED, Etgen AM. Long-term behavioral consequences of brief, repeated neonatal isolation. Brain Res. 2007 Jan 12; 1128(1):139-47.

Yang EJ, Harris AZ, Pettit DL. Synaptic kainate currents reset interneuron firing phase. J Physiol. 2007 Jan 1; 578(Pt 1):259-73.